Neuropathic complaints have various causes that need to be differentiated, and targeted treatment planning requires knowledge as to the individual triggering factor or factors. A distinction also needs to be drawn between isolated neuropathy on the one hand, such as local pressure to a minor or major nerve as may be present in an entrapment, and systemic conditions affecting the whole nervous system, on the other hand.

We examine the need for surgical relief in isolated nerve injuries with the possibility of regeneration using low-level laser therapy or intervention with biosignalling aimed towards nerve fibre regeneration.

Systemic damage requires overcoming the cause, with treatment mainly focusing on systemic cell regeneration capacity.